Opportunity Information: Apply for RFA RM 25 003
The NIH Director’s Transformative Research Awards (R01, Clinical Trial Optional) support highly innovative, high-impact research projects that aim to create new scientific paradigms, significantly improve clinical approaches, or develop transformative technologies. This award, part of NIH's High-Risk, High-Reward Research Program, encourages bold and unconventional ideas without requiring preliminary data.
Applications are welcome across all areas relevant to NIH’s mission, including behavioral, social, biomedical, applied, and formal sciences, whether the focus is basic, translational, or clinical research. The program seeks proposals demonstrating potential for broad and significant impact based on strong rationale.
To promote diversity and reach a wide range of applicants, individuals from underrepresented backgrounds and various institutions across the U.S. are encouraged to apply. The process includes a blinded peer review, where investigator and institutional identities are withheld during initial evaluation stages.
Eligible applicants include U.S.-based organizations such as federal agencies, tribal governments (non-federally recognized), regional and community-based organizations. Foreign organizations and non-U.S. components of U.S. institutions are not eligible to apply, though foreign components, as defined by NIH policy, are permitted within a U.S.-based application.Apply for RFA RM 25 003
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "NIH Directors Transformative Research Awards (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.310.
- This funding opportunity was created on 2025-06-16.
- Applicants must submit their applications by 2025-09-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants also applied for:
Applicants who have applied for this opportunity (RFA RM 25 003) also looked into and applied for these:
| Funding Opportunity |
|---|
| NIGMS National and Regional Resources (R24 - Clinical Trial Not Allowed) Apply for PAR 25 416 Funding Number: PAR 25 416 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Tobacco Regulatory Science Small Grant Program for New Investigators (R03 Clinical Trial Optional) Apply for RFA OD 25 008 Funding Number: RFA OD 25 008 Agency: National Institutes of Health Category: Health Funding Amount: $75,000 |
| Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed) Apply for PAR 25 437 Funding Number: PAR 25 437 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Studies (U01 Clinical Trial Not Allowed) Apply for RFA AR 25 013 Funding Number: RFA AR 25 013 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: Regenerative Medicine Innovation Project (RMIP) Investigator-Initiated Clinical Trials (UH3 Clinical Trial Optional) Apply for RFA AR 25 014 Funding Number: RFA AR 25 014 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Single Source: National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD) (U24 Clinical Trial Not Allowed) Apply for RFA AG 26 002 Funding Number: RFA AG 26 002 Agency: National Institutes of Health Category: Health Funding Amount: $9,230,000 |
| Expanding the Target Landscape by Drugging the Undruggable (R21 Clinical Trial Not Allowed) Apply for PAR 25 442 Funding Number: PAR 25 442 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Preventive Health and Health Services Block Grant – 2025 CDC-RFA-PW-25-2500 Apply for CDC RFA PW 25 2500 Funding Number: CDC RFA PW 25 2500 Agency: Centers for Disease Control-PHIC Category: Health Funding Amount: Case Dependent |
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