Opportunity Information: Apply for RFA DA 24 014
The National Institutes of Health (NIH) funding opportunity RFA-DA-24-014, titled "Mechanisms and Targets at the Intersection of HIV and Substance Use (R21 Clinical Trials Not Allowed)," supports short, exploratory basic research projects that focus on how HIV infection and addictive substances interact in the brain. The central goal is to understand the biological signaling pathways and molecular mechanisms through which drugs of abuse and HIV converge to alter brain function, drive neuropathological changes, and contribute to neurocognitive impairment. A key emphasis is on mechanistic work at the intersection of neuroscience, virology, and addiction biology, including topics like HIV-host protein interactions and post-translational modifications that may change cellular behavior in the central nervous system (CNS).
This opportunity is designed to push the field toward identifying actionable targets and strategies, not only by clarifying underlying mechanisms but also by encouraging the discovery and early development of new chemical or biological approaches that could prevent, reduce, or mitigate CNS complications linked to HIV infection in the context of substance use disorders. In practical terms, that means projects might investigate how specific drugs or classes of addictive substances modify HIV-related signaling in brain cells, how those changes affect neuronal or glial function, and which molecular nodes in these pathways could be targeted to blunt harmful outcomes. While the work can be highly translational in the sense of pointing toward interventions or protective strategies, the FOA explicitly excludes clinical trials, keeping the scope on preclinical, mechanistic, and early-stage discovery research rather than testing interventions in human trial settings.
The award mechanism is an NIH R21, which generally fits high-impact, early-stage ideas where investigators need support to generate foundational data, validate emerging targets, or test novel approaches that could later scale into larger projects. The funding instrument is a grant, and the activity category is listed under education and health, with CFDA number 93.279. The award ceiling is $275,000. The original closing date for applications was 2023-08-09, and the opportunity was created on 2022-12-16.
Eligibility is broad and includes a wide range of organizations that can contribute to this research area. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities/Indian housing authorities. It also includes Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments). Nonprofit organizations are eligible whether or not they have 501(c)(3) status (as long as they are not institutions of higher education), and both for-profit organizations (other than small businesses) and small businesses may apply. The FOA also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and non-domestic (non-U.S.) entities (foreign organizations). This broad eligibility reflects the multidisciplinary nature of the topic and the value of diverse institutional perspectives in addressing overlapping HIV and substance use burdens.
Overall, this FOA targets basic, mechanism-driven studies on the HIV-substance use overlap in the CNS, with an eye toward uncovering biological leverage points and enabling novel preventative or mitigating strategies for HIV-associated neurological complications exacerbated by addictive drugs, while clearly keeping the work outside the scope of clinical trials.Apply for RFA DA 24 014
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Mechanisms and Targets at the Intersection of HIV and Substance Use (R21 Clinical Trials Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2022-12-16.
- Applicants must submit their applications by 2023-08-09. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the funding opportunity title and number?
The opportunity is a National Institutes of Health (NIH) funding opportunity announcement (FOA) numbered RFA-DA-24-014, titled "Mechanisms and Targets at the Intersection of HIV and Substance Use (R21 Clinical Trials Not Allowed)."
What is the main purpose of this FOA?
This FOA supports short, exploratory basic research projects focused on how HIV infection and addictive substances interact in the brain. The overall aim is to understand the biological signaling pathways and molecular mechanisms through which drugs of abuse and HIV converge to alter brain function, drive neuropathological changes, and contribute to neurocognitive impairment.
What scientific area does this FOA focus on?
The FOA emphasizes mechanistic research at the intersection of neuroscience, virology, and addiction biology, specifically within the central nervous system (CNS).
What kinds of research questions are encouraged?
Projects are expected to be mechanism-driven and may examine how specific drugs or classes of addictive substances modify HIV-related signaling in brain cells, how these changes affect neuronal or glial function, and which molecular nodes in these pathways could be targeted to blunt harmful outcomes.
What does the FOA mean by focusing on "mechanisms and targets"?
It means the work should clarify underlying biological mechanisms (for example, signaling pathways and molecular interactions) and also move the field toward identifying actionable targets and strategies that could eventually help prevent, reduce, or mitigate CNS complications linked to HIV infection in the context of substance use disorders.
Is this opportunity focused on basic research or clinical research?
It is focused on basic, mechanistic research and early-stage discovery. While projects may be translational in the sense that they point toward interventions or protective strategies, the FOA explicitly excludes clinical trials.
Are clinical trials allowed under this FOA?
No. The FOA is labeled "Clinical Trials Not Allowed," and it states that it excludes clinical trials, keeping the scope on preclinical, mechanistic, and early-stage discovery research rather than testing interventions in human trial settings.
What types of biological topics are specifically highlighted?
The FOA highlights topics such as HIV-host protein interactions and post-translational modifications that may change cellular behavior in the CNS, alongside broader work on biological signaling pathways and molecular mechanisms at the HIV-substance use intersection.
What is the intended outcome or impact of funded projects?
Funded projects are intended to advance understanding of how HIV and drugs of abuse converge in the brain to affect function and pathology, and to help identify biological leverage points (actionable targets) and early strategies or approaches that could ultimately help mitigate HIV-associated neurological complications worsened by substance use.
Does the FOA support development of new approaches or agents?
Yes. In addition to clarifying mechanisms, the FOA encourages discovery and early development of new chemical or biological approaches that could prevent, reduce, or mitigate CNS complications linked to HIV infection in the context of substance use disorders (without conducting clinical trials).
What award mechanism is used for this opportunity?
The award mechanism is an NIH R21, which is generally used to support high-impact, early-stage ideas where investigators need support to generate foundational data, validate emerging targets, or test novel approaches that could later scale into larger projects.
What is the funding instrument?
The funding instrument is a grant.
What is the activity category for this opportunity?
The activity category is listed under education and health.
What is the CFDA number associated with this opportunity?
The CFDA number listed is 93.279.
What is the maximum award amount (award ceiling)?
The award ceiling is $275,000.
When was this opportunity created?
The opportunity was created on 2022-12-16.
What was the original application closing date?
The original closing date for applications was 2023-08-09.
Who is eligible to apply?
Eligibility is broad and includes many organization types, including: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; and public housing authorities/Indian housing authorities.
Are Native American tribal entities eligible?
Yes. Eligible applicants include Native American tribal governments (federally recognized) and Native American tribal organizations (other than federally recognized tribal governments).
Are nonprofits eligible to apply?
Yes. Nonprofit organizations are eligible whether or not they have 501(c)(3) status, as long as they are not institutions of higher education.
Are for-profit organizations eligible?
Yes. Both for-profit organizations (other than small businesses) and small businesses may apply.
Are minority-serving institutions and similar organizations eligible?
Yes. The FOA highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are listed among eligible applicant types.
Can federal agencies apply?
Yes. The FOA lists eligible federal agencies among the eligible applicant types.
Are U.S. territories or possessions eligible?
Yes. Regional organizations and U.S. territories or possessions are included in the eligibility list.
Are non-U.S. (foreign) organizations eligible?
Yes. The FOA includes non-domestic (non-U.S.) entities (foreign organizations) as eligible applicants.
What research setting or system is emphasized?
The FOA emphasizes the central nervous system (CNS), including how HIV and addictive substances interact in the brain and influence brain cells such as neurons and glia.
Does the FOA require projects to be interdisciplinary?
The FOA emphasizes mechanistic work at the intersection of neuroscience, virology, and addiction biology, reflecting a multidisciplinary approach to the HIV-substance use overlap in the CNS.
Is the focus limited to a single drug of abuse?
The FOA describes work involving "specific drugs or classes of addictive substances," indicating that multiple substances or substance classes may be relevant as long as the project addresses how they interact with HIV-related mechanisms in the brain.
What distinguishes this FOA from intervention-testing opportunities?
This FOA is designed to support preclinical, mechanistic, and early-stage discovery research. It encourages identification of targets and early development of approaches, but it does not support clinical trials or testing interventions in human trial settings.
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