Opportunity Information: Apply for RFA DA 19 019
The HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional) grant opportunity (Funding Opportunity Number RFA-DA-19-019) is a National Institutes of Health program led by the National Institute on Drug Abuse (NIDA) that uses the SBIR mechanism to fund small businesses developing practical, research-driven technologies aimed at addressing the opioid crisis. The central goal is to accelerate innovations that can prevent opioid misuse, improve treatment and recovery outcomes, reduce overdose deaths, and lessen the broader harms opioids have caused to individuals, families, and communities. The program sits within the broader NIH HEAL (Helping to End Addiction Long-term) Initiative, which focuses on speeding up scientific solutions to addiction and pain.
This opportunity is structured around the SBIR R43/R44 pathway, meaning it supports both early-stage feasibility work and more advanced development toward commercialization. In practice, applicants can propose Phase I-type activities (proof of concept, prototype feasibility, early validation) and Phase II-type activities (further R and D, refinement, scaling, and preparation for real-world implementation). The "clinical trial optional" designation indicates that projects may include clinical trial work if it is appropriate for the technology and stage of development, but applicants are not required to run a clinical trial to be eligible. The program is positioned for companies building tangible products or technology-enabled services that translate research into deployable tools, consistent with NIDA's research and development mission and the FOA's stated topical areas.
Eligibility is limited to United States small business concerns that meet SBIR requirements and have the technical capacity to carry out the proposed research and development. Foreign institutions (non-U.S. entities) are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible. However, "foreign components" as defined by the NIH Grants Policy Statement may be permitted, which typically means a portion of the work can occur outside the U.S. under specific circumstances and with appropriate justification and approvals, while the applicant organization itself must remain a U.S. small business.
From an administrative standpoint, this is a discretionary grant program under the NIH, categorized under education and health, with CFDA numbers 93.279 and 93.350. The opportunity was created on 2018-12-10 and had an original closing date of 2021-09-08. While the provided source data does not list an award ceiling or the expected number of awards, the intent is clearly to fund multiple small business projects that can contribute meaningful, scalable solutions to the opioid epidemic through technology development and related translational research.Apply for RFA DA 19 019
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279, 93.350.
- This funding opportunity was created on 2018-12-10.
- Applicants must submit their applications by 2021-09-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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| Funding Opportunity |
|---|
| HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R41/R42 - Clinical Trial Optional) Apply for RFA DA 19 020 Funding Number: RFA DA 19 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Justice Community Opioid Innovation Network (JCOIN) Clinical Research Centers (UG1 Clinical Trial Optional) Apply for RFA DA 19 025 Funding Number: RFA DA 19 025 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,500,000 |
| HEAL Initiative Limited Competition: Behavioral Research to Improve MAT: Ancillary Studies to Enhance Behavioral or Social Interventions to Improve Adherence to Medication Assisted Treatment for Opioid Use Disorders (R01, Clinical Trials Optional) Apply for RFA AT 19 007 Funding Number: RFA AT 19 007 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| HEAL Initiative: Sleep and Circadian-Dependent Mechanisms Contributing to Opiate Use Disorder (OUD) and Response to Medication Assisted Treatment (MAT) (U01 Clinical Trial Optional) Apply for RFA HL 19 029 Funding Number: RFA HL 19 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| HEAL Initiative: Effectiveness Trials to Optimize, Implement, Scale, and Sustain the Collaborative Care Model for Individuals with Opioid Use Disorders and Mental Health Conditions (U01 Clinical Trial Required) Apply for RFA MH 19 525 Funding Number: RFA MH 19 525 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Sleep and Circadian-Dependent Mechanisms Contributing to Opiate Use Disorder (OUD) and Response to Medication Assisted Treatment (MAT) (R01 - Clinical Trial Not Allowed) Apply for RFA HL 19 028 Funding Number: RFA HL 19 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Physical Sciences-Oncology Network (PS-ON): Physical Sciences-Oncology Projects (PS-OP) (U01 Clinical Trial Optional) Apply for PAR 19 101 Funding Number: PAR 19 101 Agency: National Institutes of Health Category: Education, Health Funding Amount: $499,999 |
| Cancer Tissue Engineering Collaborative: Enabling Biomimetic Tissue-Engineered Technologies for Cancer Research (R01 Clinical Trial Optional) Apply for PAR 19 113 Funding Number: PAR 19 113 Agency: National Institutes of Health Category: Education, Health Funding Amount: $400,000 |
| Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (R21 Clinical Trial Optional) Apply for PA 19 111 Funding Number: PA 19 111 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Outcomes in Cancer Treatment-Related Cardiotoxicity (R01 Clinical Trial Optional) Apply for PA 19 112 Funding Number: PA 19 112 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIH Pathway to Independence Award (Parent K99/R00 - Independent Clinical Trial Not Allowed) Apply for PA 19 130 Funding Number: PA 19 130 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Laboratories for Early Clinical Evaluation of Pharmacotherapies for Substance Use Disorders (UG1 Clinical Trial Required) Apply for RFA DA 19 018 Funding Number: RFA DA 19 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| Academic Research Enhancement Award for Undergraduate-Focused Institutions (R15 - Clinical Trial Required) Apply for PAR 19 133 Funding Number: PAR 19 133 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| End-of-Life and Palliative Needs of Adolescents and Young Adults (AYA) with Serious Illnesses (R01 Clinical Trial Optional) Apply for PAR 19 136 Funding Number: PAR 19 136 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise (R41/R42 - Clinical Trial Not Allowed) Apply for RFA DA 19 030 Funding Number: RFA DA 19 030 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Analytical Tools and Approaches for (Multidimensional) Scholarly Research Assessment and Decision Support in the Biomedical Enterprise (R43/R44 - Clinical Trial Not Allowed) Apply for RFA DA 19 031 Funding Number: RFA DA 19 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Revisions for Incorporation of Novel NCI-Supported Technology to Accelerate Cancer Research (U2C Clinical Trial Optional) Apply for RFA CA 19 028 Funding Number: RFA CA 19 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Drug Discovery For Nervous System Disorders (R01 Clinical Trials Not Allowed) Apply for PAR 19 147 Funding Number: PAR 19 147 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Drug Discovery For Nervous System Disorders (R21 Clinical Trial Not Allowed) Apply for PAR 19 146 Funding Number: PAR 19 146 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Bioengineering Research Grants (BRG) (R01 Clinical Trial Required) Apply for PAR 19 159 Funding Number: PAR 19 159 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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